IndraLab

Statements

NEDD4L inhibits KCNQ1. 5 / 6
| 5
reach
"For initial proof-of-concept, we utilized YFP-tagged KCNQ1, which is known to be down-regulated by NEDD4L ."
33169015
reach
"NEDD4L significantly decreased KCNQ1 surface density (assessed by fluorescent bungarotoxin binding to an extracellular epitope tag) and total expression (YFP fluorescence), and both effects were reversed by enDUB-O1 (Fig. 1d-f)."
33169015
reach
"KCNQ1 is downregulated by NEDD4L and ITCH with distinct polyubiquitin signatures."
39345403
reach
"Similarly, Nedd4-2 decreased KCNQ1 and KCNE1 mediated currents and KCNQ1 protein abundance in the cell membrane."
21231794
reach
"Differential impact of enDUBs on reversing KCNQ1 functional downregulation by NEDD4L and ITCH."
39345403