IndraLab

Statements

DEPTOR binds OTUB1. 11 / 11
2 | 4 5
biogrid
No evidence text available
29382726
reach
"OTUB1 specifically interacts with DEPTOR via its N-terminal domain, removes the Ub chain on DEPTOR and stabilizes DEPTOR via DUB activity in an Asp88 dependent but not Cys91 dependent manner."
32140262
sparser
"We found that OTUB1 directly interacted with DEPTOR via its N-terminal domain, deubiquitinated DEPTOR, and thereby stabilized DEPTOR in a Cys-91-independent but Asp-88-dependent manner, suggesting that OTUB1 targets DEPTOR for deubiquitination via a deubiquitinase activity-independent non-canonical mechanism."
29382726
sparser
"The interaction between OTUB1 and DEPTOR was enhanced when the cells were treated with amino acids."
29382726
reach
"OTUB1 can directly bind to DEPTOR through the N-terminal domain, which can thereby enable the deubiquitination of DEPTOR, increasing the DEPTOR expression level and inhibiting the activity of mTORC1 (Zhao et al., 2018)."
37251574
sparser
"Lysine ubiquitination by SidC and SdcA promotes interactions between OTUB1 and DEPTOR, an inhibitor of the MTORC1 pathway, thus suppressing MTORC1 signaling."
38818749
biogrid
No evidence text available
29382726
sparser
"OTUB1 can directly bind to DEPTOR through the N-terminal domain, which can thereby enable the deubiquitination of DEPTOR, increasing the DEPTOR expression level and inhibiting the activity of mTORC1 ( xref )."
37251574
sparser
"OTUB1 specifically interacts with DEPTOR via its N-terminal domain, removes the Ub chain on DEPTOR and stabilizes DEPTOR via DUB activity in an Asp88-dependent but not Cys91-dependent manner (Fig. xref )."
32140262
reach
"We found that OTUB1 directly interacted with DEPTOR via its N-terminal domain, deubiquitinated DEPTOR, and thereby stabilized DEPTOR in a Cys-91-independent but Asp-88-dependent manner, suggesting that OTUB1 targets DEPTOR for deubiquitination via a deubiquitinase activity independent non canonical mechanism."
29382726
reach
"The interaction between OTUB1 and DEPTOR was enhanced when the cells were treated with amino acids."
29382726