IndraLab

Statements

USP22 activates HIF1. 6 / 6
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"USP22 boosts the stability and transcriptional activity of HIF-1α under hypoxia through deubiquitination and induces upregulation of HIF-1α downstream genes."
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"USP22 positively regulates c-Myc, androgen receptor, and HIF-1α actions to promote breast cancer, prostate cancer, and HCC progression [16, 53, 54]."
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"USP22 enhances the stability and transcriptional activity of HIF-1α under hypoxia through deubiquitination, and it induces upregulation of HIF-1α downstream genes ( Figure 3 ) (86)."
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"Under hypertrophic stress conditions, USP22 enhances the stability of HIF-1α through its deubiquitination activity, which further activates the TAK1-(JNK1/2)/P38 signaling pathway to lead to cardiac hypertrophy."
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"G protein α12 elevates USP22 expression in hepatocytes by activating hypoxia-inducible factor 1α (HIF1α) [195]."
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"USP22 enhances the stability and transcriptional activity of HIF-1α under hypoxia through deubiquitination and induces upregulation of HIF-1α downstream genes."
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