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Terbinafine inhibits KCNH2. 12 / 13
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"Interestingly, CZ66 did not enhance the antifungal activities of other ergosterol synthesis inhibitors, such as cerulenin (an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A) (25) (see Fig. S1A in the supplemental material), fluvastatin (an inhibitor of Hmg1) (26) (Fig. S1B), or terbinafine (an inhibitor of Erg1) (27) (Fig. S1C)."
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"As expected, terbinafine efficiently inhibited Erg1 within 30 min of incubation as monitored by an increase in squalene levels."
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"The allylamine terbinafine, which selectively inhibits squalene epoxidase Erg1 within the ergosterol biosynthetic pathway, is mainly used to treat dermatomycoses, whereas its effectiveness in other fungal infections is limited."
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"In contrast, terbinafine inhibits ERG1 , decreasing ergosterol production and squalene accumulation in the plasma membrane, which increases the brittleness of the plasma membrane, impairing its structure and function."
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"Terbinafine, an allylamine drug ( xref A, xref ), inhibits Erg1 and leads to ergosterol depletion and accumulation of squalene, which is fungicidal for filamentous fungi but fungistatic for most Candida species [ xref , xref , xref ]."
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"Terbinafine, an allylamine drug (Figure 6A, Table 2), inhibits Erg1 and leads to ergosterol depletion and accumulation of squalene, which is fungicidal for filamentous fungi but fungistatic for most Candida species [98,99,100]."
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"In contrast, terbinafine inhibits ERG1, decreasing ergosterol production and squalene accumulation in the plasma membrane, which increases the brittleness of the plasma membrane, impairing its structure and function."
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"We found that terbinafine (an inhibitor of Erg1) (Ryder, 1992) could decrease the MIC value of FLC in the presence of FNZ (Figure 2, Supplementary Figure S2I), but cerulenin (an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A) (Nomura et al., 1972) could not (Figure 2, Supplementary Figure S2J)."
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"These include terbinafine (TER) that inhibits the ERG1 gene product, fenpropimorph (FEN) that inhibits Erg2p, and lovastatin (LOV) that inhibits Hmg1p."
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"To further validate this hypothesis, we inhibited the biosynthesis of lanosterol and toxic sterol through the inhibition of Erg1 by terbinafine ( xref , xref )."
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"Interestingly, with terbinafine, a drug that inhibits Erg1 catalysis, the first step in the ergosterol biosynthesis pathway, COL completely eliminated FoG and increased susceptibility (RAD 20) by 7 mm."
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"Terbinafine, an allylamine, inhibits the erg1 + product squalene epoxidase XREF_BIBR, which acts upstream of the erg11 + product lanosterol demethylase that is inhibited by azoles XREF_BIBR."
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