IndraLab

Statements

Terbinafine inhibits KCNH2. 7 / 7
1 | 4 2
reach
"Interestingly, with terbinafine, a drug that inhibits Erg1 catalysis, the first step in the ergosterol biosynthesis pathway, COL completely eliminated FoG and increased susceptibility (RAD 20) by 7 mm."
33471513
reach
"Terbinafine, an allylamine, inhibits the erg1 + product squalene epoxidase XREF_BIBR, which acts upstream of the erg11 + product lanosterol demethylase that is inhibited by azoles XREF_BIBR."
23145048
sparser
"To further validate this hypothesis, we inhibited the biosynthesis of lanosterol and toxic sterol through the inhibition of Erg1 by terbinafine ( xref , xref )."
33524398
ctd
No evidence text available
28551711
reach
"The allylamine terbinafine, which selectively inhibits squalene epoxidase Erg1 within the ergosterol biosynthetic pathway, is mainly used to treat dermatomycoses, whereas its effectiveness in other fungal infections is limited."
35837730
reach
"These include terbinafine (TER) that inhibits the ERG1 gene product, fenpropimorph (FEN) that inhibits Erg2p, and lovastatin (LOV) that inhibits Hmg1p."
18757808
sparser
"The allylamine terbinafine, which selectively inhibits squalene epoxidase Erg1 within the ergosterol biosynthetic pathway, is mainly used to treat dermatomycoses, whereas its effectiveness in other fungal infections is limited."
35837730