IndraLab

Statements

USP17L2 inhibits SNAI1. 3 / 3
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"Dub3 mediated Snail stabilization is disrupted by a Dub3 specific inhibitor, WP1130, and Snail driven metastasis is inhibited in breast cancer."
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"DUB3 promotes Snail degradation and stabilization, as well as the cyclin A protein stabilization through the removal of the polyubiquitin chains from cyclin A, thus inducing cell-cycle progression for the proliferation of NSCLC [117]."
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"DUB3 (official symbol USP17L2) was shown to promote breast cancer invasion and metastasis via stabilizing Snail1 in a CDK4/6 activity-dependent manner ."
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