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STAMBP binds MC1R. 2 / 2
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"[5] a-Melanocyte stimulating hormone (a-MSH), which binds to MSH-R, a G protein coupled receptor also known as the melanocortin-1 receptor (MC1-R) [6] activates AC, thereby increasing the amount of cAMP in the cell."
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"Binding of aMSH to MC1R may be functionally protective against UV-induced DNA damage as aMSH pretreatment of melanocytes can reduce generation of UV-induced oxidative byproducts, an effect that was absent in melanocytes expressing loss-of-function MC1R, suggesting the mechanism mediating this susceptibility may be independent of pigmentation."
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