IndraLab

Statements

USP15 activates TP53. 9 / 10
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"Conversely, whereas USP4 and USP15 target p53 inhibiting ligases ARF-BP1 [XREF_BIBR] and MDM2 [XREF_BIBR], respectively, USP11 stabilizes p53 [XREF_BIBR] as well as several other tumor suppressors including PML [XREF_BIBR], BRCA2 [XREF_BIBR] and Mre11 complex members MRE11 & RAD50 [XREF_BIBR]."
26503449
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"USP15 can stabilize p53 through deubiquitination (XREF_FIG) and upregulate the p53 transcriptional activity, in turn promoting the expression of p21 (XREF_FIG)."
27893708
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"29 USP15 knockdown abolished p53 stabilization by TGF-beta signaling (XREF_FIG) and suppressed the transcriptional activity of p53 (XREF_FIG)."
27893708
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"Our results confirmed a previous report that overexpression of USP15 can upregulate the transcriptional activity of p53."
27893708
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"Overexpression of USP15 increased the half-life of endogenous p53, but overexpression of the inactive USP15 C269S failed to increase the half-life of p53 (XREF_FIG)."
27893708
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"Crucially, ectopic expression of either p53 R175H or USP15 promoted p53 triggered apoptosis in human cervical cancer cells."
31749782
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"Western blot analysis indicated that overexpression of Flag-USP15 increased the stability of p53, in turn leading to an increased expression of p21, a p53 regulated target gene (XREF_FIG)."
27893708
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"TIFAB Regulates USP15 Mediated p53 Signaling during Stressed and Malignant Hematopoiesis."
32101751
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"USP15 knockdown disrupted p53 stability and p21 synthesis mediated by TGF-beta, indicating that TGF-beta modulated p53 stability through upregulation of USP15 synthesis (XREF_FIG)."
27893708