IndraLab

Statements

FSCN1 activates KCNA2. 4 / 4
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"Blocking increased eIF4G2 through microinjection of eIF4G2 siRNA into the injured DRG attenuated SNL-induced downregulation of DRG MOR and Kv1.2 and development and maintenance of nociceptive hypersensitivities."
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"These behavioral effects may be attributed to direct compensation of SNL-induced reduction of Kv1.2 protein and inhibition of SNL-induced upregulation of Kv1.2 AS RNA in the injured DRG."
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"To examine the role of Kcna2 antisense RNA in neuropathic pain induction, we subjected rats to SNL 4 weeks after DRG viral injection, as our pilot work showed that the level of Kcna2 SE RNA fragment was too low to block SNL-induced Kcna2 antisense RNA expression before that time."
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"For example, reduction of pain behaviors and repetitive firing in the SNL model was also achieved by countering the SNL-induced downregulation of the Kcna2 potassium channel (Zhao et al., 2013)."
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