IndraLab

Statements

USP19 inhibits Interferon. 7 / 7
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"USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination."
28391724
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"Furthermore, USP19 negatively regulates type I interferon (IFN) signaling and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation [27,28]."
| PMC
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"Previous studies have indicated that EV71 infection induces the up-regulation of USP19, which negatively regulates the antiviral type I interferon signalling by removing K-63 polyubiquitin chains from TRAF3 35."
30194441
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"Previously, it has been shown that USP19 negatively regulates RNA virus-triggered type I IFN induction by deubiquitinating Beclin-1 and impairing RIG-I-MAVS/VISA association in certain human cell lines ."
31511519
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"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
34436957
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"By removing K11 linked chains at K437 from Beclin-1, an essential factor of autophagic initiation, USP19 induces autophagy and inhibits the production of type I IFN [XREF_BIBR]."
33402098
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"The reduced expression of USP19 following MI and CHF could result in reduced autophagic response and could promote IFN signaling and NF-κB activation induced by tumor necrosis factor or interleukin 1β."
| PMC