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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTUB1 activates MDM4. 3 / 3

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"Interestingly, MDMX induced by Otub1 can localize to mitochondria in addition to the cytosol, enhance p53 phosphorylation at S46 (p53S46P) and promote mitochondria mediated apoptotic pathway."

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"Also, induced overexpression of Otub1 drastically prolonged the half-life of MDMX as determined by half-life assays."

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"Together, these results suggest that Otub1 also induces mitochondrial mediated apoptosis by stabilizing MDMX and relocalizing it to mitochondria to induce mitochondria mediated apoptosis."

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OTUB1 activates MDM4. 3 / 3

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