IndraLab

Statements


OTUB1 activates MDM4. 3 / 3
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"Interestingly, MDMX induced by Otub1 can localize to mitochondria in addition to the cytosol, enhance p53 phosphorylation at S46 (p53S46P) and promote mitochondria mediated apoptotic pathway."

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"Also, induced overexpression of Otub1 drastically prolonged the half-life of MDMX as determined by half-life assays."

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"Together, these results suggest that Otub1 also induces mitochondrial mediated apoptosis by stabilizing MDMX and relocalizing it to mitochondria to induce mitochondria mediated apoptosis."