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USP22 deubiquitinates COPS5. 4 / 5
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"On the other hand, USP22 deubiquitinates CSN5 and regulates PD-L1 protein levels through the USP22-CSN5-PD-L1 axis."
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"Furthermore, when the PD-L1 protein is depleted, USP22 deubiquitinates CSN5 and controls the level of PD-L1 protein through the USP22-CSN5-PD-L1 axis, thereby strengthening antitumour immune reactions [75]."
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"USP22 can deubiquitinate PD-L1 itself or CSN5 for their stabilization [233] (Figure 3)."
| PMC
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"USP22 deubiquitinates CSN5 polyubiquitin chains and stabilizes CSN5 protein, resulting in enhanced PD-L1 expression [102]."
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