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(R,R,R)-alpha-tocopherol inhibits NFKB1. 4 / 7
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"Vitamin E promotes a barrier function and anti-inflammatory responses by binding the regulatory domain of protein kinase Calpha (pkcalpha) (a regulator and antagonist of heart failure) and decreases the activation of NF-kb, a proinflammatory transcription factor, causing the generation of cytokines and chemokines and mast cell activation."
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"Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE, suggesting that activation of NF-kB plays an important role in the pathogenesis of EAE, while inhibitors of NF-kB activation may have therapeutic importance in MS. This finding poses intriguing implications in view of the recent evidence that vitamin E blocks NFkB activation in different cell types (Hattori et al., 1995; Lee et al., 2001)."
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"Increased dietary vitamin E leads to decreased activation of hepatic NFkB by the peroxisome proliferator ciprofibrate."
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"When Jurkat cells were treated with okac acid subsequent to the preincubation with vitamin E derivatives, only a-tocopheryl succinate but not any other vitamin E derivatives were found to inhibit the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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