IndraLab

Statements

(R,R,R)-alpha-tocopherol inhibits NFKB1. 7 / 7
3 | 4
reach
"Vitamin E promotes a barrier function and anti-inflammatory responses by binding the regulatory domain of protein kinase Calpha (pkcalpha) (a regulator and antagonist of heart failure) and decreases the activation of NF-kb, a proinflammatory transcription factor, causing the generation of cytokines and chemokines and mast cell activation."
29504360
reach
"Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE, suggesting that activation of NF-kB plays an important role in the pathogenesis of EAE, while inhibitors of NF-kB activation may have therapeutic importance in MS. This finding poses intriguing implications in view of the recent evidence that vitamin E blocks NFkB activation in different cell types (Hattori et al., 1995; Lee et al., 2001)."
12168685
ctd
No evidence text available
16135673
ctd
No evidence text available
15025948
reach
"Increased dietary vitamin E leads to decreased activation of hepatic NFkB by the peroxisome proliferator ciprofibrate."
15742903
ctd
No evidence text available
17936189
reach
"When Jurkat cells were treated with okac acid subsequent to the preincubation with vitamin E derivatives, only a-tocopheryl succinate but not any other vitamin E derivatives were found to inhibit the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8264337