IndraLab

Statements

ANK2 binds SCN2A. 2 / 2
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reach
"Interaction analysis of the hcASD genes with the pASD genes revealed abundant interactions between ANK2, SCN2A, and POGZ and the pASD genes."
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reach
"Dysfunction in ANK2 is highly implicated in ASD, yet it remains unclear how ANK2, independently or by converging with the high-risk ASD gene SCN2A or other ASD-associated genes, contributes to ASD etiology.Given the strong association between SCN2A and ANK2 in ASD, and the importance of ankyrin-B-mediated scaffolding of Na 1.2 at dendrites for proper dendritic and synaptic function, it is important to understand how ankyrin-B targets to the dendritic membrane to allow for Na 1.2 localization."
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