IndraLab

Statements

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one inhibits CASP1. 5 / 5
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"Furthermore, R406 inhibited caspase-1 activity after CaP particle exposure, as assessed by quantitative live cell imaging (XREF_FIG D), with no effect on VSMC death (Supplement Fig."
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"The SYK inhibitor R406 reduced IL-1beta release and caspase-1 activation in CaP particle treated VSMCs, indicating that SYK activation occurs upstream of and is required for caspase-1 activation."
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"As shown in Fig. 5 A, C-E, ASC oligomer and p20/pro-caspase-1 were significantly inhibited by R406 similar to FGF21."
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"On the other hand, LFM-A13 and R406 suppressed IL-1beta secretion and caspase-1 activation without affecting pro-IL-1beta accumulation in THP-1-Mphi (XREF_FIG)."
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"Compared to vehicle, R406 significantly suppressed caspase-1 activation in platelets from SS mice (p<0.001) and to a lesser extent in AA mice (p=0.047), indicating that R406 interferes with NLRP3 inflammasome activation in collagen-activated platelets from sickle cell mice."
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