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Statements

RvD1 inhibits STAT1. 3 / 3
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"In inflamed human adipose tissue, RvD1 treatment increased MAPK activity and inhibited the activity of STAT-1 and related inflammatory genes without affecting the anti-inflammatory effects of IL-10 (Titos et al., 2016)."
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"Of interest, RvD1 blocked STAT-1 and its target inflammatory genes (i.e. CXCL9) as well as persistent STAT3 activation without affecting the IL-10 anti-inflammatory response characterized by inhibition of IL-6, IL-1beta, IL-8 and TNFalpha."
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"This result is consistent with another study that demonstrated that the incubation of inflamed obese visceral adipose tissues and human macrophages with RvD1 (a diastereomer, differing from AT-RvD1 on[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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