IndraLab

Statements

BAP1 is phosphorylated on S592. 21 / 21
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"The C-terminal domain of p53 (residues 293–393) induced Sp1 stabilization strongly linked to BAP1 Ser 592 phosphorylation."
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"These findings indicated that cathepsin K inhibition increases Sp1 stabilization via BAP1 Ser 592 phosphorylation."
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"In vivo and in vitro assays indicated that the forced expression of PLK-3 increased the phosphorylation of BAP1 at serine 592 and caspase-8 expression."
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"A large-scale proteomic analysis identified BAP1 phosphorylation at Ser592, an SQ/TQ motif in ATM/ATR kinase consensus phosphorylation site, after IR xref ."
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"ODN induced the phosphorylation of BAP1 at Ser 592 and enhanced the interaction of Sp1 and BAP1, resulting in Sp1 deubiquitination and destabilization."
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"Phosphorylation of BAP1 at S592 is an important regulatory mechanism to dissociate BAP1 from chromatin and regulate-specific genes during DNA replication and repair xref ."
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"In particular, the phosphatidylinositol 3-kinase-related kinases ATM/ATR/DNA-PK phosphorylate BAP1 at S592, which is one of the five serines in its carboxyl terminus that are modified in response to DNA damage [ xref , xref , xref , xref ]."
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rlimsp
"Eletr et al.27 reported that BAP1 is phosphorylated at serine 592 following DNA damage, that phospho-BAP1 causes deubiquitination of H2AK119ub1, and that this signal promotes the HR pathway."
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"Furthermore, BAP1 is phosphorylated at Ser592 in response to HU-induced replication stress xref ."
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"BAP1 is also phosphorylated at serine 592 in response to DNA damage."
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"Phosphorylation of BAP1 at serine 592 in response to DNA damage by ATM/ATR kinases retains BAP1 in the nucleus; however, it is predominantly dissociated from chromatin, suggesting that this phosphorylation removes BAP1 from specific promoters [ xref ]."
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rlimsp
"BAP1 is also phosphorylated at serine 592 in response to DNA damage."
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rlimsp
"Phosphorylation of BAP1 at serine 592 in response to DNA damage by ATM/ATR kinases retains BAP1 in the nucleus; however, it is predominantly dissociated from chromatin, suggesting that this phosphorylation removes BAP1 from specific promoters [26]."
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No evidence text available
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"BAP1 is phosphorylated at serine 592 in S-phase following DNA damage."
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"In this study we characterized DNA damage-induced phosphorylation of BAP1 at serine 592 (pS592) and the cellular outcomes of this modification."
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No evidence text available
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"BAP1 is phosphorylated at serine 592 in S-phase following DNA damage."
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"ODN treatment induced the phosphorylation of BAP1 at Ser 592 residue in a time-dependent manner ( xref B)."
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"To investigate the functional role of Ser 592 phosphorylation in BAP1, we used the BAP1 mutant (S592A)."
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"S592A BAP1 failed to upregulate Sp1 and Bax expression, indicating that the phosphorylation of BAP1 at Ser 592 is crucial for Sp1 stability in ODN-treated cells ( xref C)."
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