"In cancer, there is an increase in the activity of PI3K-AKT axis, and TSC1 and TSC2 is inhibited by AKT, allowing mTORC1 activation and subsequently activation of P70S6K1 and EIF4e."
"Moreover, in mammalian cells in culture, co-overexpression of TSC1 and TSC2 prevents amino acid dependent activation of S6K1 [XREF_BIBR]."
"It will be of great interest to determine the molecular nature of S6K1 inhibition by the tuberin-hamartin complex in the absence of mitogenic stimuli."
"Hamartin with alanine mutations in the three cyclin dependent kinase 1 phosphorylation sites increased the inhibition of p70S6 kinase by the hamartin and tuberin complex."
"Hamartin with alanine mutations in the three cyclin-dependent kinase 1 phosphorylation sites increased the inhibition of p70S6 kinase by the hamartin-tuberin complex."
"Over-expression of TSC1 and TSC2 also markedly inhibited S6K1, positioning TSC1 and TSC2 upstream of S6K1."
"Incubation of RMCs with 1,25 (OH) 2 D 3 for 48 h increased VDR expression (p < 0.05), restored the expression of TSC1 and TSC2 and 4E-BP1, and blocked the aberrant upregulation of Rheb, mTOR and p70S6K."