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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP15 increases the amount of CD274. 2 / 2

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"The tumor of the Usp15 -/- chimeric mice had upregulated expression of PD-L1 and CXCL12 (XREF_FIG)."

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"Excessive IFN-gamma production in USP15 deficient mice promotes expression of the immunosuppressive molecule PD-L1 and the chemokine CXCL12, causing accumulation of T-bet + regulatory T cells and CD11b + Gr-1 + myeloid derived suppressor cells at tumor site."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...