IndraLab

Statements

BAP1 activates DNA Damage. 6 / 6
| 6
reach
"BAP1 modulates double-strand DNA damage repair."
31283845
reach
"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
32944533
reach
"Here, we show that BAP1 promotes the repair of ultraviolet (UV)-induced DNA damage via its deubiquitination activity in various cell types, including primary melanocytes."
35637285
reach
"In summary, reduced BAP1 levels cause cells to accumulate DNA damage, a process that normally triggers apoptosis."
30455474
reach
"In heterozygous BAP1 conditions, as in the individuals of the families with the BAP1 cancer syndrome, the reduced BAP1 dosage impairs both the DNA repair, accumulating DNA damage, and the apoptotic response."
32206569
reach
"Molecularly, Bap1 null melanoma cell lines have increased DNA damage measured by gammaH2aX and hyperubiquitination of histone H2a."
30156010