IndraLab

Statements

BAP1 activates DNA Damage. 10 / 10
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"Molecularly, Bap1 null melanoma cell lines have increased DNA damage measured by gammaH2aX and hyperubiquitination of histone H2a."
30156010
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"In heterozygous BAP1 conditions, as in the individuals of the families with the BAP1 cancer syndrome, the reduced BAP1 dosage impairs both the DNA repair, accumulating DNA damage, and the apoptotic response."
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"In summary, reduced BAP1 levels cause cells to accumulate DNA damage, a process that normally triggers apoptosis."
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"Here, we show that BAP1 promotes the repair of ultraviolet (UV)-induced DNA damage via its deubiquitination activity in various cell types, including primary melanocytes."
35637285
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
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"These results demonstrated that PARP1 recruits BAP1 to sites of UV-induced DNA damage."
37009801
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"BAP1, a ubiquitin C-terminal hydrolase domain, can promote the repair of DNA damage induced by ultraviolet light (UV) through deubiquitination activity."
37834477
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"The study showed that BAP1 is recruited to sites of UV-induced DNA damage via H2A-K119-Ub and PARP1 to promote DNA repair and that both DUB activity and PARP1-mediated poly(ADP-ribosyl)ation are critical for this function of BAP1 ."
36754982
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"As already said, BAP1 modulates DNA damage repair mechanism."
38410609
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"BAP1 modulates double-strand DNA damage repair."
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