IndraLab

Statements

USP19 activates TARDBP. 4 / 4
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"These findings strongly suggest that the USP19-mediated MAPS pathway conducts a specific sorting of misfolded TDP-43, leading to its secretion as soluble and free aggregates rather than through exosomes.The exact molecular and cellular mechanisms by which cells select misfolded proteins for secretion via the USP19 dependent MAPS pathway remain enigmatic."
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"Our investigations revealed that USP19-WT promotes the secretion of soluble and aggregated forms of misfolded TDP-43 without associated cell mortality."
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"Consistently, we found that USP19-WT promotes the secretion of free aggregates as well as soluble misfolded TDP-43 in the extracellular medium."
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"As anticipated, little or no TDP-43 signal was observed when USP19-ΔTM was expressed.In conclusion, these findings indicate that USP19-WT expression promotes the secretion of both soluble and aggregated forms of misfolded TDP-43."
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