IndraLab

Statements

1b activates KCNH2. 1 / 1

| 1

reach

"If hERG 1a/1b heteromers represent a significant fraction of channels contributing to I Kr, down-regulation of 1b would enhance sensitivity to hERG blockers up to four-fold and increase the risk for arrhythmia by having a predominant population of more drug sensitive hERG 1a channels rather than the relatively less sensitive hERG 1a/1b channels."

18776039

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

1b activates KCNH2. 1 / 1

INDRA sources:

Databases

Reading