IndraLab

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RNA1 polyprotein activates KCNH2. 1 / 1

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"If hERG 1a/1b heteromers represent a significant fraction of channels contributing to I Kr, down-regulation of 1b would enhance sensitivity to hERG blockers up to four-fold and increase the risk for arrhythmia by having a predominant population of more drug sensitive hERG 1a channels rather than the relatively less sensitive hERG 1a/1b channels."

18776039

INDRA sources:

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IndraLab

Statements

RNA1 polyprotein activates KCNH2. 1 / 1

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