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Ceramide inhibits KCNH2. 3 / 4
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"For instance, ceramide down-regulates the HERG potassium channel XREF_BIBR, and affect the resting membrane potential of thyroid FRTL-cells by processes involving protein kinase C zeta XREF_BIBR."
23620740
eidos
"The mechanisms proposed for ceramide-induced modulation of hERG1 properties include indirect effects on cell expression , altered channel trafficking to the plasma membrane , and the translocation of the channel into lipid rafts14 ,15 , but the molecular mechanism of hERG1 blockade by ceramides remains unknown ."
33658490
eidos
"Ceramides induce hERG1 block by a conformational selection mechanism through a lipophilic pathway ."
33658490