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USP37 activates NFE2L2. 5 / 5
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"Mechanistically, USP37 modulates the stability of NRF2 through enzymatic activity-dependent deubiquitination."
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"Additionally, knocking down USP37 caused NRF2 protein level downregulation (Fig. 1e)."
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"Figure 1f depicts that USP37 expression significantly promoted NRF2 protein stability."
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"Additionally, USP37, rather than its enzymatically inactive mutant, promoted NRF2 protein stability (Fig. 2c and Figure S2a)."
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"This, in turn, activates the NRF2-ARE signaling pathway, which has been associated with chemotherapy resistance.Our findings suggest that the NRF2-ARE signaling pathway activation, regulated by USP37-mediated NRF2 stabilization, may be responsible for the observed chemotherapy resistance in hepatoma cells."
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