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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 bound to ELAVL1 activates TP53. 2 / 2

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"Binding of HuR to the p53 mRNA 3 ' UTR, especially at a site adjacent to the miR-125b target site, causes dissociation of the p53 mRNA from the RNA induced silencing complex (RISC) and inhibits the miR-125b-mediated translation repression of p53."

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"According to this competitive interaction, when 7SL was silenced, HuR binding to TP53 mRNA was increased, which subsequently promoted p53 translation, resulting in increased cell cycle arrest and senescence [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...