IndraLab

Statements


TP53 bound to ELAVL1 activates TP53. 2 / 2
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"According to this competitive interaction, when 7SL was silenced, HuR binding to TP53 mRNA was increased, which subsequently promoted p53 translation, resulting in increased cell cycle arrest and senescence [XREF_BIBR]."

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"Binding of HuR to the p53 mRNA 3 ' UTR, especially at a site adjacent to the miR-125b target site, causes dissociation of the p53 mRNA from the RNA induced silencing complex (RISC) and inhibits the miR-125b-mediated translation repression of p53."