IndraLab

Statements

USP1 activates homologous recombination. 3 / 3
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"However, the direct mechanism by which USP1 and UAF1 promotes HR remains to be elucidated [XREF_BIBR]."
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"In contrast, inhibition of USP1 by ML323 decreased the I-SceI-induced HR frequency to 0.81% (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Our work provides a direct functional link between the deubiquitinating enzyme complex in the FA pathway and the RAD51 dependent HR repair pathway.ResultsUSP1 or UAF1 depletion inhibits HR repair by primarily affecting downstream of RAD51 foci formationUSP1 and UAF1 are known to regulate HR repair,12,22 and consistently, we found that USP1 or UAF1 knockdown reduces HR repair efficiency in the cell based HR reporter assay."
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