IndraLab

Statements

USP12 binds CREBBP. 9 / 9
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"Thus, we further confirmed the interaction between USP12 and CBP."
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"Moreover, we demonstrated that in IFN signaling, USP12 interacted with CBP but not with either p-STAT1 or TCPTP ( xref ), suggesting that USP12 affects the p-STAT1 and TCPTP interaction through targeting CBP."
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"Together, these findings demonstrated that USP12 constitutively binds with CBP in cells."
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"In bone marrow-derived macrophages (BMDMs) isolated from mice and RAW264.7 cells, endogenous USP12 also interacted with endogenous CBP ( xref )."
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"Importantly, USP12 constitutively binds with CBP in mouse primary lung and liver cells ( xref )."
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"The results showed that endogenous USP12 interacted with endogenous CBP in intact cells, and IFNα treatment promoted USP12 nuclear accumulation ( xref and xref )."
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"In our mass spectroscopy analysis, we noticed an interaction between USP12 and CBP."
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"We also demonstrated that USP12 interacted with CBP, but not either p-STAT1 or TCPTP, suggesting that the regulation of USP12 on both TCPTP binding and p-STAT1 levels is through CBP."
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"USP12 interacts with CBP and blocks the acetyltransferase activity of CBP."
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