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Hydroxychloroquine inhibits inflammatory response. 68 / 68
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"For example, a 2020 study reported that hydroxychloroquine, which is commonly used to prevent SLE flares, inhibited trained immunity by suppressing H3K27ac and H3K4me3 of inflammation-related genes ."
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"Because MC activation plays a key role in the inflammatory response and vascular permeability in the skin [35] , HCQ may reduce the erythema and inflammation associated with rosacea partly by suppress[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus , HCQ interferes in the process of antigen presentation ( Fig. 1 ) and possibly attenuating the inflammatory response by significantly decreasing the production of pro-inflammatory factors in COVID-19 patients ."
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"To explore whether HCQ inhibits inflammation activation by regulating the TLR4/NF-κB signaling pathway, western blot analysis was performed."
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"Hydroxychloroquine and thalidomide did not reduce inflammation and immune activation without ART, but led to a greater decline in CD4 + T-cell counts and an increase in viral replication."
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"Taken together, these results indicate that after TBI, HCQ administration inhibits the inflammatory response, affects the expression of TLR4 and inhibits the activation of TLR4/NF-κB signaling pathway.Microglial activation plays an important role in neuroinflammation after TBI."
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"New data from cohort studies seem to show the beneficial effects of drugs such as tocilizumab and hydroxychloroquine, which inhibit the inflammatory response through immunomodulation, thus reducing the incidence of cytokine storms ."
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"Mode of action of CQ / HCQ CQ / HCQ has multiple mode of mechanisms that may be useful in treatment of SARS-CoV-2 [ 45,63 ] : a b c d e HCQ not only attenuate the inflammatory response but also decrease the level of cytokines which is generally higher in patients infected with SARS-CoV-2 ."
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"Just when we thought we might have a shot at " normalcy, " we learn that ventilators are not the best course of treatment and that hydroxychloroquine reduces inflammation, but does not cure."
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"As mentioned above, DNAse1 inhibitors, hydroxychloroquine (HCQ), and COX-2 inhibitors could suppress the induction of this pro-inflammatory response [64]."
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"While high-dose hydroxychloroquine can suppress the inflammatory response implicated in clinical symptoms, whether it also affects antiviral immunity requires further evaluation.What question did this study address?"
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"Hydroxychloroquine ( 7 ) and thalidomide ( 41 ) did not reduce inflammation and immune activation without ART , but led to a greater decline in CD4 + T-cell counts and an increase in viral replication ."
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"Just when we thought we might have a shot at `` normalcy , '' we learn that ventilators are not the best course of treatment and that hydroxychloroquine reduces inflammation , but does not cure ."
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"Through these functions, HCQ might prevent systemic inflammation."
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"Additionally, C57Bl/6 mice were treated with HCQ by oral gavage before cSiO 2 exposure, and the ability of HCQ to prevent lung injury and inflammation was assessed."
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"Therefore, if this unique immune quiescent state can be pharmacologically induced locally, it will provide an excellent women oriented strategy against HIV infection To our knowledge, this is the first research article evaluating in vivo, an innovative trackable implant that can provide controlled delivery of hydroxychloroquine (HCQ) to successfully attenuate vaginal T lymphocyte activation and inflammation in a rabbit model as a potential strategy to induce an " immune quiescent " state within the FGT for the prevention of HIV infection."
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"Gomez-Gutman et al. showed that hydroxychloroquine decreases renal inflammation, blood pressure, and renal injury, but does not decrease levels of anti-dsDNA antibodies in the NZBWF1 mouse model (Gómez-Guzmán et al., 2014)."
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"This suggests that HCQ may suppress the inflammatory response to renal fibrosis via the NF-κB signaling pathway.To elucidate the mechanism of action of HCQ in anti-fibrosis in HK-2 cells, p-PI3K and p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that HCQ may partially attenuate the inflammatory response by decreasing the levels of pro-inflammatory mediators.The pathogenesis of CKD is complicated and includes immune inflammation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The use of HCQ reduces the risk of thrombosis and diminishes vascular inflammation and endothelial dysfunction in a murine model of antiphospholipid syndrome (APS) [XREF_BIBR]."
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"Hydroxychloroquine (HCQ), a lysosomal inhibitor used in autophagy treatment, reduces inflammation and BBB damage in traumatic brain injury."
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"HCQ treatment reduces airway inflammation in vivo [27] and inhibits inflammation-induced PRL2 degradation [11]."
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"Our study demonstrated that HCQ cannot inhibit the acute inflammation induced by SLE IgG or decrease the anti‐inflammatory effect of GCs in patients with lupus."
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"Two potential pathways were inferred to be involved in the protective effect of hydroxychloroquine in CAD : (a) hydroxychloroquine may activate ERK5 (encoded by MAPK7) to prevent endothelial inflammation via inhibition of cell adhesion molecule expression 24; and (b) hydroxychloroquine may inhibit endosomal activation of NADPH oxidase in response to pro inflammatory agonists (TNF-alpha and IL-1beta) and may decrease production of pro inflammatory cytokines in stimulated immune cells 25."
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"HCQ is often used in combination with other medications to reduce inflammation in patients with osteoarticular disease.19,20 Many of these drugs make patients more susceptible to viral infections including influenza and its associated conditions."
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"Hydroxychloroquine can reduce the inflammatory response and cytokine storm (aggressive inflammatory response with the release of a large amount of pro inflammatory cytokines) in patients severely infected with SARS-CoV-2 by blocking T-cell stimulation, and thus decreasing cytokine production."
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"These results indicate that HCQ reduces PEDV induced autophagy and inflammatory response."
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"Furthermore, hydroxychloroquine was shown to inhibit the inflammatory response of the organism by blocking the cytokine storm associated with severe progression of COVID-19."
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"Also, HCQ can reduce placental inflammation and improve trophoblast function, thereby decreasing placental insufficiency and enhancing maternal-fetal health in high-risk pregnancies [16]."
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"Combination therapy with MTX, sulfasalazine, and hydroxychloroquine also decreases CV risk by improving the reduction in inflammation, increase in HDL, and decrease in LDL and by enhancing the ratio of total cholesterol to HDL."
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"These results indicate that HCQ reduces PEDV-induced autophagy and inflammatory response ."
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"Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [XREF_BIBR]."
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"[22] Hence, hydroxychloroquine reduces adipocyte and islet inflammation which in turn reduces insulin resistance and insulin insufficiency and hence improves insulin sensitivity, beta cell function in type 2 diabetes."
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"HCQ lowers disease activity and inflammation in SLE, and it has been reported that early initiation of HCQ delays the onset and progression of disease and ameliorates overall survival [36–42] ."
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"Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis."
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"Meanwhile, our study showed that prednisone and HCQ combination cannot completely inhibit the inflammatory response of CD8 T cells in patients with pSLE."
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"Although hydroxychloroquine can reduce neutrophil-derived oxidants and suppress inflammation (Hurst et al., 1988; Jančinová et al., 2015), it can cause systemic oxidative stress, and this could be problematic in treating COVID-19 patients (Klouda and Stone, 2020)."
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"In mouse models of APS, HCQ reduces thrombosis, vascular inflammation and endothelial dysfunction (34)."
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"Although hydroxychloroquine can reduce neutrophil-derived oxidants and suppress inflammation ( Hurst et al ., 1988 ; Jancinov a et al ., 2015 ) , it can cause systemic oxidative stress , and this could be problematic in treating COVID-19 patients ( Klouda and Stone , 2020 ) ."
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"By inhibiting autophagic activity, HCQ may reduce inflammation and innate immunity, inhibit the activation of T cells, restore the T helper 17/T regulator balance, restrict the production of pro-inflammatory cytokines, and modulate co-stimulatory molecules."
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"Hydroxychloroquine has also been reported to reduce the inflammatory response and cytokine storm in vitro, to reduce proinflammatory cytokine production, to activate anti-SARS-CoV-2 T cells, to inhibit virus-cell junction by increasing endosomal pH, and to inhibit pH-dependent steps of viral replication.2 3 Due to these mechanisms of action, it has been used in the treatment of COVID-19 during the pandemic process."
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"In patients with COVID-19, hydroxychloroquine decreases the inflammatory response and cytokine storm, but overdose causes toxicity and mortality."
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"The mesangial cell inflammatory response may contribute to subsequent podocyte and tubular injury, and HCQ could relieve the injury by inhibiting the inflammatory response."
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"Recommendations on the use of HCQ are based on current clinical practices as literature is scarce and limited to some cases for cutaneous (7–10) and musculoskeletal involvement (11–13) Although the underlying mechanism in sarcoidosis is still largely unknown, it is suggested that HCQ suppresses inflammation (6,12) with potentially fewer side effects (14)."
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"Hydroxychloroquine may also be used to decrease inflammation (Lawson et al., 2015, Lawson et al., 2017)."
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"Hydroxychloroquine (HCQ) has been used for many years to reduce inflammation in the treatment of patients with multiple rheumatologic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)."
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"We hypothesized that the daily administration of low doses of acetylsalicylic acid (ASA 81mg) or hydroxychloroquine (HCQ 200mg) would reduce inflammation thereby decreasing HIV target cells at the FGT."
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"Since our previous studies demonstrated that the deposition of SLE IgG on tissues plays a crucial role in multiorgan and tissue damage in SLE, 31 we investigated whether HCQ inhibits inflammation induced by SLE IgG."
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"Thus, HCQ interferes in the process of antigen presentation (XREF_FIG) and possibly attenuating the inflammatory response by significantly decreasing the production of pro inflammatory factors in COVID-19 patients."
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"We conducted a pilot study in Kenya with the objectives of assessing if the non steroidal anti-inflammatory drugs acetylsalicylic acid (ASA) or hydroxychloroquine (HCQ) could reduce T cell IA, HIV target cell numbers and inflammation at the genital tract."
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"In a nutshell, no beneficial effect has been observed in COVID-19 patients treated with favipiravir.The antimalarial drug hydroxychloroquine reduces cytokines to give symptomatic relief in inflammation to COVID-19 patients [116,117]."
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"HCQ attenuates I/R induced renal inflammation."
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"Therefore, it is reasonable to believe that HCQ may reduce renal inflammation in IgAN patients by inhibiting TLR signaling in mucosal and renal tissues, modulating immune responses, increasing intracellular pH, stimulating nitric oxide synthesis, and reducing the production of Gd-IgA1."
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"The results suggested that HCQ attenuated inflammation by regulating T cells lipid metabolism and T differentiation, which was attributed to promoting the interaction of GRK2 with PI3K in the cytoplasm of T lymphocyte and inhibiting PI3K-AKT axis."
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"In experimental SARS-CoV infections, HCQ was able to limit inflammation markers even though it has not affected viral titers in the lungs of infected mice (Maisonnasse et al., 2020) ."
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"We hypothesized that hydroxychloroquine would reduce cardiovascular inflammation in this highly selected and well-defined patient population.The trial design has been published previously [ 10 ]."
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"Hydroxychloroquine (HCQ) has long been used to reduce inflammation in patients with RA and lupus."
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"Thus, HCQ interferes in the process of antigen presentation ( Fig. 1 ) and possibly attenuating the inflammatory response by significantly decreasing the production of pro-inflammatory factors in COVI[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hydroxychloroquine , which has been used successfully in the treatment of many autoimmune diseases , can suppress inflammation and might also be beneficial in hand osteoarthritis ."
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"Hydroxychloroquine decreased the activation of metabolism-related PI3K-AKT-mTOR and inflammation-related JAK2-STAT3-SOCS3 pathways in the T cells and liver tissue of AIH mice."
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"In addition, immunomodulatory or immunosuppressive treatments, such as anti-IL-6, anti-IL-6R, anti-IL-1beta, chloroquine and hydroxychloroquine inhibit the host inflammatory response by neutralizing the role of cytokines or their cognate receptors to further reduce immune response triggered by the virus."
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"Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by improving insulin secretion; and hydroxychloroquine reduce the risk of coronary heart disease (CHD) by counteracting inflammation."
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"One candidate drug identified by these in vitro studies was hydroxychloroquine, which suppresses inflammation and cell signaling induced by the tumor necrosis factor-alpha pathway as well as fibroblast proliferation and activation (39–42)."
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"Hydroxychloroquine ( HCQ ) has long been used to reduce inflammation in patients with RA and lupus ."
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"Hydroxychloroquine Attenuates Acute Inflammation (LPS)-Induced Apoptosis via Inhibiting TRPV1 Channel/ROS Signaling Pathways in Human Monocytes."
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"For its turn, HCQ has been found to be effective in inhibiting SARS-CoV-2 infection in vitro and attenuate inflammatory response (Liu et al., 2020)."
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"( 30,31 ) Hydroxychloroquine is commonly used in rheumatologic disorders for its immunomodulatory effects , ( 32 ) and also mitigates inflammation by increasing the pH of intracellular vacuoles to disrupt antigen binding , disrupting calcium dependent intracellular signaling , ( 33 ) decreasing macrophage mediated cytokine production , ( 34 ) and inhibiting toll like receptor signaling ."
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"HCQ treatment reduced inflammation, fibrosis and immune cell infiltration in myocarditis models."
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