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Hydroxychloroquine inhibits inflammatory response. 50 / 50
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"We conducted a pilot study in Kenya with the objectives of assessing if the non steroidal anti-inflammatory drugs acetylsalicylic acid (ASA) or hydroxychloroquine (HCQ) could reduce T cell IA, HIV target cell numbers and inflammation at the genital tract."
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"Therefore, in COVID-19 patients, HCQ may also contribute to attenuating the inflammatory response."
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"Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [1]."
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"Hydroxychloroquine and thalidomide did not reduce inflammation and immune activation without ART, but led to a greater decline in CD4 + T-cell counts and an increase in viral replication."
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"Corticosteroids, LHQW, Xuebijing, IVIG, tocilizumab, sarilumab, baricitinib, vitamin D, CQ, and HCQ could also reduce inflammation."
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"Thus , HCQ interferes in the process of antigen presentation ( Fig. 1 ) and possibly attenuating the inflammatory response by significantly decreasing the production of pro-inflammatory factors in COVID-19 patients ."
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"The use of HCQ reduces the risk of thrombosis and diminishes vascular inflammation and endothelial dysfunction in a murine model of antiphospholipid syndrome (APS) [XREF_BIBR]."
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"Hydroxychloroquine can reduce the inflammatory response and cytokine storm (aggressive inflammatory response with the release of a large amount of pro inflammatory cytokines) in patients severely infected with SARS-CoV-2 by blocking T-cell stimulation, and thus decreasing cytokine production."
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"Hydroxychloroquine , which has been used successfully in the treatment of many autoimmune diseases , can suppress inflammation and might also be beneficial in hand osteoarthritis ."
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"HCQ attenuates I/R induced renal inflammation."
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"In patients with COVID-19 , hydroxychloroquine decreases the inflammatory response and cytokine storm , but overdose causes toxicity and mortality ."
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"Therefore, if this unique immune quiescent state can be pharmacologically induced locally, it will provide an excellent women oriented strategy against HIV infection To our knowledge, this is the first research article evaluating in vivo, an innovative trackable implant that can provide controlled delivery of hydroxychloroquine (HCQ) to successfully attenuate vaginal T lymphocyte activation and inflammation in a rabbit model as a potential strategy to induce an " immune quiescent " state within the FGT for the prevention of HIV infection."
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"Although hydroxychloroquine can reduce neutrophil-derived oxidants and suppress inflammation (Hurst et al., 1988; Jančinová et al., 2015), it can cause systemic oxidative stress, and this could be problematic in treating COVID-19 patients (Klouda and Stone, 2020)."
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"In addition, immunomodulatory or immunosuppressive treatments, such as anti-IL-6, anti-IL-6R, anti-IL-1beta, chloroquine and hydroxychloroquine inhibit the host inflammatory response by neutralizing the role of cytokines or their cognate receptors to further reduce immune response triggered by the virus."
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"( 30,31 ) Hydroxychloroquine is commonly used in rheumatologic disorders for its immunomodulatory effects , ( 32 ) and also mitigates inflammation by increasing the pH of intracellular vacuoles to disrupt antigen binding , disrupting calcium dependent intracellular signaling , ( 33 ) decreasing macrophage mediated cytokine production , ( 34 ) and inhibiting toll like receptor signaling ."
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"Hydroxychloroquine (HCQ) has long been used to reduce inflammation in patients with RA and lupus."
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"iNO could alleviate pulmonary hypertension through its selective pulmonary vasodilation.Corticosteroids, LHQW, Xuebijing, IVIG, tocilizumab, sarilumab, baricitinib, vitamin D, CQ, and HCQ could also reduce inflammation."
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"Hydroxychloroquine decreased the activation of metabolism-related PI3K-AKT-mTOR and inflammation-related JAK2-STAT3-SOCS3 pathways in the T cells and liver tissue of AIH mice."
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"While high-dose hydroxychloroquine can suppress the inflammatory response implicated in clinical symptoms, whether it also affects antiviral immunity requires further evaluation.What question did this study address?"
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"Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [XREF_BIBR]."
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"Just when we thought we might have a shot at `` normalcy , '' we learn that ventilators are not the best course of treatment and that hydroxychloroquine reduces inflammation , but does not cure ."
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"Additionally, C57Bl/6 mice were treated with HCQ by oral gavage before cSiO 2 exposure, and the ability of HCQ to prevent lung injury and inflammation was assessed."
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"One candidate drug identified by these in vitro studies was hydroxychloroquine, which suppresses inflammation and cell signaling induced by the tumor necrosis factor-alpha pathway as well as fibroblast proliferation and activation (39–42)."
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"These results indicate that HCQ reduces PEDV-induced autophagy and inflammatory response ."
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"Hydroxychloroquine Attenuates Acute Inflammation (LPS)-Induced Apoptosis via Inhibiting TRPV1 Channel/ROS Signaling Pathways in Human Monocytes."
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"Hydroxychloroquine (HCQ) has been used for many years to reduce inflammation in the treatment of patients with multiple rheumatologic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)."
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"In patients with COVID-19, hydroxychloroquine decreases the inflammatory response and cytokine storm, but overdose causes toxicity and mortality."
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"For its turn, HCQ has been found to be effective in inhibiting SARS-CoV-2 infection in vitro and attenuate inflammatory response (Liu et al., 2020)."
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"Just when we thought we might have a shot at " normalcy, " we learn that ventilators are not the best course of treatment and that hydroxychloroquine reduces inflammation, but does not cure."
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"In experimental SARS-CoV infections, HCQ was able to limit inflammation markers even though it has not affected viral titers in the lungs of infected mice (Maisonnasse et al., 2020) ."
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"To explore whether HCQ inhibits inflammation activation by regulating the TLR4/NF-κB signaling pathway, western blot analysis was performed."
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"For its turn, HCQ has been found to be effective in inhibiting SARS-CoV-2 infection in vitro and attenuate inflammatory response."
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"We hypothesized that the daily administration of low doses of acetylsalicylic acid (ASA 81mg) or hydroxychloroquine (HCQ 200mg) would reduce inflammation thereby decreasing HIV target cells at the FGT."
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"The fact that this study was open label and lacked a placebo limits interpretation , and additional analysis is required to determine whether HCQ reduces inflammatory response ."
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"For example, a 2020 study reported that hydroxychloroquine, which is commonly used to prevent SLE flares, inhibited trained immunity by suppressing H3K27ac and H3K4me3 of inflammation-related genes ."
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"Besides, in silico platforms have suggested that diflunisal, nabumetone, niflumic acid, and valdecoxib may be suitable for the treatment of T1DM; phenoxybenzamine and idazoxan for the treatment of T2DM by improving insulin secretion; and hydroxychloroquine reduce the risk of coronary heart disease (CHD) by counteracting inflammation."
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"Hydroxychloroquine has also been reported to reduce the inflammatory response and cytokine storm in vitro, to reduce proinflammatory cytokine production, to activate anti-SARS-CoV-2 T cells, to inhibit virus-cell junction by increasing endosomal pH, and to inhibit pH-dependent steps of viral replication."
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"The results suggested that HCQ attenuated inflammation by regulating T cells lipid metabolism and T differentiation, which was attributed to promoting the interaction of GRK2 with PI3K in the cytoplasm of T lymphocyte and inhibiting PI3K-AKT axis."
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"Hydroxychloroquine ( 7 ) and thalidomide ( 41 ) did not reduce inflammation and immune activation without ART , but led to a greater decline in CD4 + T-cell counts and an increase in viral replication ."
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"Taken together, these results indicate that after TBI, HCQ administration inhibits the inflammatory response, affects the expression of TLR4 and inhibits the activation of TLR4/NF-κB signaling pathway.Microglial activation plays an important role in neuroinflammation after TBI."
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"Corticosteroids , LHQW , Xuebijing , IVIG , tocilizumab , sarilumab , baricitinib , vitamin D , CQ , and HCQ could also reduce inflammation ."
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"Hydroxychloroquine ( HCQ ) has long been used to reduce inflammation in patients with RA and lupus ."
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"Thus , HCQ interferes in the process of antigen 11 presentation ( Fig. 1 ) and possibly attenuating the inflammatory response by significantly 12 decreasing the production of pro-inflammatory factors in COVID-19 patients ."
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"Thus, HCQ interferes in the process of antigen presentation (XREF_FIG) and possibly attenuating the inflammatory response by significantly decreasing the production of pro inflammatory factors in COVID-19 patients."
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"These results indicate that HCQ reduces PEDV induced autophagy and inflammatory response."
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"Two potential pathways were inferred to be involved in the protective effect of hydroxychloroquine in CAD : (a) hydroxychloroquine may activate ERK5 (encoded by MAPK7) to prevent endothelial inflammation via inhibition of cell adhesion molecule expression 24; and (b) hydroxychloroquine may inhibit endosomal activation of NADPH oxidase in response to pro inflammatory agonists (TNF-alpha and IL-1beta) and may decrease production of pro inflammatory cytokines in stimulated immune cells 25."
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"Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis."
33327296
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"Although hydroxychloroquine can reduce neutrophil-derived oxidants and suppress inflammation ( Hurst et al ., 1988 ; Jancinov a et al ., 2015 ) , it can cause systemic oxidative stress , and this could be problematic in treating COVID-19 patients ( Klouda and Stone , 2020 ) ."
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"Hydroxychloroquine, an original antimalarial drug, prevents inflammation caused by lupus erythematosus and rheumatoid arthritis."
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"Hydroxychloroquine has also been reported to reduce the inflammatory response and cytokine storm in vitro, to reduce proinflammatory cytokine production, to activate anti-SARS-CoV-2 T cells, to inhibit virus-cell junction by increasing endosomal pH, and to inhibit pH-dependent steps of viral replication.2,3 Due to these mechanisms of action, it has been used in the treatment of COVID-19 during the pandemic process."
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