IndraLab

Statements

OTOF binds CACNA1D. 7 / 7
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sparser
"The top two protein pairs (key proteins) for the PoS are BDNF-GDNF and OTOF-CACNA1D and for the AcouStim process BDNF-NTRK2 and TH-CALB1."
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sparser
"The top2 protein pair (OTOF-CACNA1D) is directed to synaptic fine regulation."
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sparser
"The C2D domain of Otoferlin interacts with the calcium channel Cav1.3 in a calcium-dependent manner."
33204247
sparser
"Candidate key proteins of the PoS process are BDNF-GDNF and OTOF-CACNA1D."
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trips
"Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3."
19004828
sparser
"In the PoS process, the protein pair BDNF-GDNF is important for the survival of the cells, and the protein pair OTOF-CACNA1D is important for the fine regulation of synaptic transmission."
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reach
"Otoferlin simultaneously binds multiple copies of the calcium voltage-gated channel subunit alpha1 D (CACNA1D, also known as Cav1.3 neuronal L-type channel) of the calcium ion channel of neurons and arms of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex) protein complex."
37736859