IndraLab
Statements
sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."
sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."
sparser
"Moreover, immunohistochemical (IHC) analysis showed negativity for epithelial markers, such as Cytokeratin AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1; therefore, further immunohistochemical markers were evaluated, and the conclusive diagnosis was based on a diffuse speckled nuclear positivity for NUT1 (clone C52B1)."
sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."