IndraLab

Statements



sparser
"Malignant spindle cells tested negative for Pan-cytokeratin (CK), CK-CAM5.2, STAT6, CD34, S100, HMB45, and SOX10."

sparser
"Regarding intermediate filament panels, both jejunal and peritoneal tumors expressed vimentin, CK-AE1/AE3, CK-CAM5.2, and CK7."

sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."

sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."

sparser
"Immunohistochemically, tumor cells were negative for almost all markers such as CK‐AE1/AE3, CKCAM5.2, EMA, calretinin, desmin, α‐SMA, D2‐40, CD34, S‐100, and neurofilament."

sparser
"Immunohistochemistry shows staining of tumor cells with antibodies against smooth muscle actin, vimentin, S-100, epithelial membrane antigen, p63, BER-EP4, and CK-CAM 5.2.[ xref ]"

sparser
"The small round cells were positive for CK-CAM5.2, cytokeratin 8/18, ERG, and CD31, and negative for HHV-8, SOX-10, TTF-1, S-100, GATA-3, p40, CK5/6, napsin A, with retained SDHB and SMARCA4 expression."

sparser
"Moreover, immunohistochemical (IHC) analysis showed negativity for epithelial markers, such as Cytokeratin AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1; therefore, further immunohistochemical markers were evaluated, and the conclusive diagnosis was based on a diffuse speckled nuclear positivity for NUT1 (clone C52B1)."

sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."

sparser
"Most epithelial cells stained positive with the K903 mAb which binds high molecular weight cytokeratins (CK5 and CK14) as well as with Cam 5.2 mAb which binds low molecular weight CK (CK8 and 18) and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"A first panel of immunohistochemical (IHC) analysis was performed, demonstrating negativity for epithelial markers AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1."

sparser
"As indicated in Figure xref , the spindled jejunal cancer cells revealed diffuse immunoreactivity for vimentin, cytokeratin (CK)-AE1/AE3, CK-CAM5.2, CK7, and programmed death-ligand 1 (PD-L1, clone: 22C3)."

sparser
"CK7, CK-AE1/AE3, CK-CAM5.2, CK-34bE12, and vimentin were also diffusely expressed."