IndraLab

Statements

USP25 activates APP. 8 / 8
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"The positive effect of USP25 on APP protein is detectable only when the proteasome is active; treatment of transfected cells with the inhibitor MG132 abolishes this effect (XREF_FIG), suggesting that USP25 rescues APP from proteasomal degradation."
22590560
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"Besides, we have found that USP25 can also promote AD by enhancing Aβ generation through inhibiting the ubiquitination and lysosomal degradation of APP and BACE1 [39] ."
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"16 USP25 promotes the cleavage of amyloid precursor protein (APP) and the generation of amyloid‐β by reducing the ubiquitination and degradation of APP and BACE1, thereby exacerbating AD neuropathology in 5×FAD mice."
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"We investigated whether USP25 prevents APP degradation under ER-stress conditions."
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"Together, these findings suggest that the activation of A23187 mediated ERAD resulted in APP degradation, and that USP25 inhibits APP degradation by the proteasome."
25740315
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"Similarly to what occurs with CD3delta, overexpression of USP25 increases APP half-life."
22590560
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"83 Zheng's study demonstrated that USP25 promoted the cleavage of APP as well as the generation of Aβ through deubiquitination of BACE1."
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"83 Zheng's study demonstrated that USP25 promoted the cleavage of APP as well as the generation of Aβ through deubiquitination of BACE1."
36756718