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15-deoxy-Delta(12,14)-prostaglandin J2 inhibits CASP1. 4 / 4
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"15d-PGJ2 inhibited caspase-1 autoproteolysis (monitored by generation of the p10 fragment) as well as maturation and secretion of IL-1beta in LT treated cells at a step subsequent to NF-kappaB signaling (XREF_FIG)."
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"We report that the eicosanoid 15-deoxy-Delta 12,14 -prostaglandin J2 (15d-PGJ2) and related cyclopentenone prostaglandins inhibit caspase-1 activation by the NLRP1 and NLRP3 inflammasomes."
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"Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1beta through induction of a cellular state inhibitory to caspase-1 proteolytic function."
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"Given the ability of this compound to inhibit multiple inflammasomes, we hypothesized that 15d-PGJ2 could inhibit caspase-1 directly."
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