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"However , recently , Setz et al. could show that ubiquitin carboxyl-terminal hydrolases 7 ( USP7 ) - and 47 ( USP47 ) - specific inhibitors P22077 and PR-619 are able to impair GAG processing and affect infectivity of released HIV virions , underscoring the importance of DUBs in HIV biology ( Setz et al ., 2017 ) ."