IndraLab

Statements

Phosphatidylinositol trisphosphate binds PDPK1. 29 / 35
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"PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane."
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"PIP3 binds and activates PDK1 and PDK2 (3-phosphoinositide dependent protein kinases 1 and 2)."
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"Next, PIP3 binds to PDK1 and AKT proteins, leading to phosphorylation of AKT protein by PDK1 and activation of numerous enzymes."
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"To further examine the regulation of Akt1 activation, we studied PDK1, an upstream regulatory kinase, whose PH domain binds to the PI 3-K product PIP3 with high affinity."
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"PIP3 also binds to 3-phosphoinositide-dependent protein kinase 1 (PDPK1, also known as Protein Kinase B)."
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"Accordingly, PIP3 can interact with PDK1 to directly activate a variety of PKC isoforms."
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"Because PDK1 binding to PIP3 is required for Akt activation [43], these data suggest that Akt is not involved in PDK1 mediated tumorigenesis."
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"PIP3 binds to AKT and PDK1, causing PDK1 to phosphorylate Ser308 and Ser473 of the AKT protein, resulting in activation of AKT."
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"PIP3 binds and localizes the 3-phosphoinositide-dependent protein kinase-1 (PDK1) to the cell membrane, along with PDK1 's targets, Akt and atypical protein kinase C (aPKC)."
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"PIP3 binds and recruits the kinases PDK1 and Akt, leading to Akt phosphorylation on T308 and S473 by PDK1 and mTORC2, respectively; both of these phosphorylation events are required for full Akt activation."
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"PDK1 exhibits constitutive kinase activity (Fruman et al., 2017), and the PIP3-dependent recruitment of PDK1 and Akt brings them to vicinity resulting in PDK1-induced Akt phosphorylation (Figure 5C)."
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"Accumulating PIP3 binds to PDK1, in turn activating the AKT-mTorc1 pathway 38."
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"PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of AKT and also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, and then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
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"The PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
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"Akt and PDK1 bind PIP3 and translocate to the membrane [XREF_BIBR, XREF_BIBR]."
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"In the membrane, the PDK1 and PIP3 complex phosphorylates AKT on thr308 XREF_BIBR."
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"Second, ceramide blocks insulin stimulated Akt translocation to the PIP3 and PDK1 complex at the plasma membrane [XREF_BIBR, XREF_BIBR]."
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"Binding of PDK1 and Akt to PIP3 further leads to the phosphorylation of Akt [42]."
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"While AKT and PDK1 bind to PIP3 at the plasma membrane, PDK1 phosphorylates the activation loop of AKT at T308."
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"This modification hampered the binding of PDK1 to PIP3, whereas deacetylated form of PDK1 displayed opposite results, thus suggesting that acetylation dependent regulation could be a common mechanism controlling activity of the membrane-lipid binding proteins."
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"AKT and PDK1 bind to PIP3 at the plasma membrane, and PDK1 phosphorylates the activation loop of AKT at Thr 308 to expose Ser 473 that is phosphorylated by several kinases (PDK2 and others) to achieve[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PDK1 and PKB and Akt bind to PIP3 and are recruited to the membrane XREF_BIBR, XREF_BIBR resulting in the phosphorylation of Akt by PDK1 and activation of Akt which leads to phosphorylation of both S6K and 4EBP1 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"PIP3 is bound by AKT which facilities its activation by PDK1."
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"Beside the PDK1 kinase activity, beta3 integrin endocytosis and FA dynamics require also the PDK1 binding to PIP3, downstream to PI3K activation."
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"A good example of feed-forward regulation is the activation of the protein kinase Akt by the lipid second messanger PIP3 (PIP3 binds Akt, which promotes Akt activation, and PIP3 also stimulates the kinase PDK1, which phosphorylates Akt and further contributes to Akt activation)."
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"The PI3K family consists of three classes, Class I, Class II and Class III, among which the Class I PI3Ks are responsible for the production of PIP3, which binds to the pleckstrin homology domain of AKT and phosphoinoside dependent protein kinase 1 (PDK1), resulting in the phosphorylation of AKT [XREF_BIBR - XREF_BIBR]."
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"PIP3, a product of PI3K, binds to AKT and leads to the membrane recruitment of the AKT, and it also binds to phosphoinositide dependent kinase 1 (PDK1) via their pleckstrin homology (PH) domains, then PDK1 phosphorylates AKT in the kinase domain (Thr 308 in AKT1)."
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"PDK1 interacts with PKCzeta and phosphorylates the kinase domain at threonine 410 and then interacts with PIP3 to create stable activation."
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"Under high amino acid availability, a Class III PI3K (Vsp34) is activated and through the recruitment of PIP3 and PDK, activates Akt, which then has two means of activating mTOR."
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