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Potassium(1+) inhibits CASP1. 9 / 10
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"NLRP3 senses decreased cytosolic potassium levels and activates caspase-1 (23)."
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"Our data demonstrate that an excess of extracellular potassium prevents adenosine dependent activation of caspase-1 as does the use of the K ATP channel blocker glyburide."
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"As shown in Figures 3D,E, high extracellular potassium concentrations suppressed caspase-1 activation and cleavage/release of IL-1β induced by C. perfringens and nigericin, but not that induced by a Salmonella mutant, which induces NLRC4-mediated activation (Liu et al., 2014)."
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"When eATP binds to the P2X7 receptor, intracellular potassium concentration decreases, causing caspase-1 to switch from being a protective agent involved in enhancing cell survival to being the source of a suicide pathway determining cell fate by pyroptosis [XREF_BIBR, XREF_BIBR]."
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"Other studies have shown that decreased levels of intracellular K+ resulted in caspase-1 activation and IL-1β release in cultured primary astrocytes and neurons ( de Rivero Vaccari et al., 2008; Silve[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Addition of extracellular potassium or the reactive oxygen scavenger NAC, both of which can prevent activation of the NLRP3 inflammasome, did not prevent activation of caspase-1 in response to infection with either the T3SS or the WT Yersinia strains (XREF_FIG and data not shown)."
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"As shown in Figure XREF_FIG, S. pneumoniae D39 induced caspase-1 activation was decreased by high extracellular potassium."
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"Studies have also shown that high levels of extracellular potassium in macrophages inhibit the activation of caspase-1 in those inflammasomes that require ASC [XREF_BIBR]."
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"For example, high potassium (150 mM) has been shown to suppress activation and cleavage of recombinant caspase-1 in vitro XREF_BIBR."
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