IndraLab

Statements

BAP1 inhibits 2'-O-methyluridine. 7 / 7
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"BAP1 promotes progenitor cell differentiation into melanocytes by increasing MITF expression and BAP1 loss may promote metastasis in UM by remodeling the epigenome to resemble that of stem-like migratory neural crest cells."
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"BAP1 knockout in mice leads to MM growth, larger tumors and increased number of metastases and BAP1 protein expression is also correlated with poor prognosis and shorter survival in RCC and cholangiocarcinoma, as well as UM (22–25)."
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"Early changes resulting in gain of chromosome 8q may activate macrophage infiltration, while sequential loss of BAP1 expression seems to drive T cell infiltration in UM."
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"Therefore, we hypothesized that decreasing BAP1 might increase the ability of UM cells to perform TEM in our model system."
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"Loss of BAP1 enhances UM transmigration."
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"Next, we used movie analysis of living cells to examine BAP1 depleted UM cells interacting with EC monolayers."
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"Interestingly, recent research has revealed that the gain of chromosomal 8q may worsen prognosis by activating macrophage infiltration, and the loss of BAP1 expression may drive T cell infiltration in UM (Gezgin et al., 2017), suggesting that immune infiltration plays a crucial role in the prognosis of UM.Emerging evidence shows that the immune microenvironment is crucial for cancer progression and response to therapeutics (Quail and Joyce, 2013)."
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