IndraLab

Statements

BAP1 inhibits 2'-O-methyluridine. 11 / 11
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"Early changes resulting in gain of chromosome 8q may activate macrophage infiltration, while sequential loss of BAP1 expression seems to drive T cell infiltration in UM."
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"BAP1 knockout in mice leads to MM growth, larger tumors and increased number of metastases and BAP1 protein expression is also correlated with poor prognosis and shorter survival in RCC and cholangiocarcinoma, as well as UM (22–25)."
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"Loss of BAP1 enhances UM transmigration."
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"Therefore, we hypothesized that decreasing BAP1 might increase the ability of UM cells to perform TEM in our model system."
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"BAP1 promotes progenitor cell differentiation into melanocytes by increasing MITF expression and BAP1 loss may promote metastasis in UM by remodeling the epigenome to resemble that of stem-like migratory neural crest cells."
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"Next, we used movie analysis of living cells to examine BAP1 depleted UM cells interacting with EC monolayers."
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"Kaler et al. analyzed scRNA-seq data from 11 UM tumor samples and confirmed that BAP1 loss can lead to an increase in PROS1 expression in class 2 UM (characterized by poor prognosis and high metastatic risk) cells while increasing MERTK expression in CD163+ macrophages (25)."
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"It has been found that mutations in BAP1, SF3B1, and EIF1AX in UM with different prognoses exhibit different types of methylation cluster status, and hypermethylation of chromosome 3 in UM is also associated with downregulation of BAP1 gene expression, which was further confirmed in vitro experiments that knockdown of BAP1 gene or deletion of the protein induces effects on methylation status in UM cells, causing UM cells to exhibit a low metastatic risk phenotype [20–22]."
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"Interestingly, recent research has revealed that the gain of chromosomal 8q may worsen prognosis by activating macrophage infiltration, and the loss of BAP1 expression may drive T cell infiltration in UM (Gezgin et al., 2017), suggesting that immune infiltration plays a crucial role in the prognosis of UM.Emerging evidence shows that the immune microenvironment is crucial for cancer progression and response to therapeutics (Quail and Joyce, 2013)."
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"A reduction of BAP1 activity causes UM cells to acquire characteristics reminiscent of stem cells, leading to upregulation of genes with stem cell-like properties and developmental processes."
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"Uveal melanoma (UM) with BAP1 inactivating mutations has a high risk of metastasis, but the mechanism behind BAP1 deficiency driving UM metastasis is unknown."
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