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P22077 inhibits USP47. 13 / 13
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"It has been reported that P22077, a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, inhibited the proliferation of HIV virus by inhibiting the function of USP47 [27]."
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"P22077, a USP7 inhibitor, has also been shown to inhibit the NF-κB and MAPKs pathways and exert important anti-inflammatory effects in vitro and in vivo by promoting K48-linked ubiquitination and TRAF6 degradation.19 Palazon-Riquelme et al9 found that in macrophages, P22077 prevents the formation and activation of inflammatory vesicles by inhibiting USP7 and USP47 and reducing ASC oligomerization and speckling."
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"We observed that P22077 inhibited IL-1beta, IL-18 and caspase-1 cleavage and release, as well as pyroptotic cell death (Fig XREF_FIG A-D), indicating that USP7 and/or the closely related DUB USP47 are important for inflammasome activation."
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"In this regard, P22077 was reported to inhibit Usp47."
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"P22077 and PR-619 are inhibitors for both USP7 and USP47 [49] ."
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"P22077 may promote the degradation of USP47 by inhibiting the auto-deubiquitinating process of USP47 28, which is supported by the finding that MG132 reverses P22077 induced USP47 degradation."
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"For example, P22077 and P5091 also inhibited USP47 with similar potency [10,77,83,87] ."
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"P22077 and PR-619 are specific inhibitors of USP7 and USP47, which inhibit Gag processing and reduce the release of infectious virions in HIV-1 infection [60]."
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"P22077-mediated inhibition of USP47 exerts cytotoxicity in leukemia cells both in vitro and in vivo [246].7.2 DUBs and cell cycle regulation."
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"Inhibiting USP47 by P22077 exerts cytotoxicity to CML cells with or without TKI resistance in vitro and in vivo ."
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"In this light, the structure of the catalytic core of USP47 also inhibited by P22077 and P50429 is a subject of great interest.Altogether, our results reveal the molecular mechanisms of USP7 inhibitio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Data from these studies demonstrate that P22077 inhibits USP7 and the closely related DUB USP47."
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"These data were consistent with the in vitro enzyme characterization data, demonstrating that PR-619 exhibits a broad inhibition profile whereas P22077 is a selective inhibitor of USP7 and USP47."
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