IndraLab

Statements


USP15 activates CD4. 3 / 3
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"USP15 deficiency promotes the activation of naive CD4 + T cells and their subsequent differentiation into the IFN-gamma-producing Th1 cells."

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"However, the USP15 deficiency promoted the TCR+CD 28 stimulated production of cytokines, such as interleukin 2 (IL-2) and interferon-gamma (IFN-gamma), in naive CD4 + T cells, as assessed by quantitative real-time RT-PCR (qRT-PCR) (XREF_FIG), intracellular cytokine staining (XREF_FIG) and ELISA (XREF_FIG)."

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"found that USP15 was abundantly expressed in immune cells, and the USP15 deficiency promoted the TCR + CD28 - stimulated production of cytokines, such as interleukin 2 (IL-2) and interferon-gamma in naive CD4 + T cells."