IndraLab

Statements

STAMBP activates MC3R. 3 / 3
| 1 2
sparser
"ACTH (1–39) or α-MSH can activate MC1R, MC3R, MC4R, and MC5R ( xref ), but MC2R can only be activated by ACTH and not by α-MSH or other analogs ( xref )."
28228747
sparser
"ACTH can activate all five receptor subtypes; of the melanocortins, only ACTH activates MC2R; ACTH as well as α-MSH, β-MSH and γ-MSH activate MC1R, MC3R, MC4R and MC5R, although with varying affinities."
28805746
reach
"MC3R signaling is bi-directionally regulated by the endogenous melanocortin receptor agonist aMSH (produced by the POMC peptide in POMC neurons) which stimulates MC3R, and the endogenous MC3R antagonist AgRP, which inhibits the MC3R."
38712101