IndraLab

Statements

COPS5 inhibits BRSK2. 7 / 7
| 7
reach
"Overexpression of Jab1 accelerated the protein degradation of BRSK2 significantly."
22609399
reach
"Moreover, exogenous Jab1 reversed BRSK2 mediated G2/M arrest, indicating that BRSK2 is involved in the regulation of cell cycle in mammalian cells."
22609399
reach
"The results suggest that Jab1 is able to reverse BRSK2 mediated G2/M phase arrest in mammalian cells.BRSK2 shares high sequence homology with two mice SAD kinases."
22609399
reach
"Importantly, treatment with proteasome inhibitor MG132 rescued BRSK2 reduction mediated by Jab1, suggesting that Jab1 induced BRSK2 degradation through proteosome pathway."
22609399
reach
"Therefore, it will be meaningful to find out whether Jab1 mediated BRSK2 degradation is associated with oncogenic processes.In conclusion, we present novel findings showing that BRSK2 directly interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22609399
reach
"However, co-expression of Myc-Jab1 decreased HA-BRSK2 immunofluorescent signal and they co-localized in cytoplasm."
22609399
reach
"In an attempt to test whether Jab1 mediates the degradation of BRSK2, we expressed the increasing doses of Jab1 in PANC-1 cells and examined endogenous BRSK2 protein level."
22609399