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Roflumilast inhibits JAK1. 2 / 2

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"The roflumilast intervention improved the tissue morphology of sepsis mice by reducing JAK and STAT-3 protein and mRNA expression [81] and, making things even more interesting, roflumilast significantly decreased the activity of STAT3, as well as Janus kinase 1 and Janus kinase 2, which are both downstream of STAT3."

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"Moreover, roflumilast significantly suppressed the activation of signal transducer and activator of transcription 3 (STAT3) and its upstream Janus kinase 1 and Janus kinase 2."

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IndraLab

Statements

Roflumilast inhibits JAK1. 2 / 2

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