IndraLab

Statements

MOT3 decreases the amount of KCNH6. 4 / 4
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"For example, MOT3, which was identified as a transcriptional repressor for sterol biosynthesis pathways, inhibited ERG2 expression under hypoxia."
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"MOT3 inhibited ERG2 expression under hypoxic conditions, therefore, in this study, ERG2 and ERG3 were integrated into MOT3 site, which significantly increased the 7-DHC titer."
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"Transcriptional analyses show that Mot3 represses transcription of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic growth."
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"As MOT3 inhibits ERG2 expression, it was knocked out to enhance pathway gene expression."
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