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OTUD6B activates Pulmonary Arterial Hypertension. 4 / 4
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"However, whether Calpain-1 is involved in Otud6b mediated PAH has not been reported in the literature.Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that is activated under hypoxia conditions and consists of β and α subunits [22]."
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"Otud6b deficiency inhibits PAH development in hypoxia mice models."
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"The knock-down effect of siOtud6b#1 is stronger than siOtud6b#2 and siOtud6b#3.To test whether the reduction of Otud6b inhibits PAH development, we targeted Otud6b (siOtud6b, GGGAATGAAGAACGCCGTT) and non-targeted control (siNC) modified anti-siRNA oligonucleotides by trachea infusion for 3 weeks."
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"Our study shows that increased Otud6b expression during hypoxia promotes the development of PAH models through a positive feedback loop between HIF-1alpha and Calpain-1."
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