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Amlexanox inhibits TBK1. 28 / 28
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"Our study provides evidence that TBK1 inhibition by amlexanox alleviates PQ-induced ALI and may be a new therapeutic strategy ."
32763286
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"Because amlexanox inhibits TBK-1, this evidence potentially points to an indirect pathway in which amlexanox increases the secretion of IL-6 from adipocytes through a cAMP / p38 dependent pathway."
33380937
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"Thus, chronic decrease in Tbk1 activity is hypothesized to be associated with increased inflammatory responses.The anti-inflammatory agent Amlexanox (AMX; Reilly et al., 2013) is an inhibitor of Tbk1 and of the closely related IKK-ε (Cheng H. et al., 2018)."
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"Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-epsilon (IKKepsilon) and TANK binding kinase 1 (TBK1)."
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"We treated WT mice with Amlexanox, which blocks TBK1 activity in vivo without affecting the activity of IKK-α or IKK-β or any other known kinases (52, 53)."
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"Blocking TBK1 and IKKepsilon during transduction of NK cells enabled their efficient transduction by VSV-G LVs as judged by YFPexpression of 40-50%, with half maximal effective concentrations of 1.1 microM (MRT67307), 5 microM (BX-795) and 24.8 microM (amlexanox)."
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"Inhibition of IKKepsilon or TBK1 (data not shown) by amlexanox was competitive for its substrate ATP (XREF_FIG), indicating that it interacts with the enzymes in the ATP binding site."
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"Inhibition of TBK1/IKKε with two different small molecules, amlexanox (Fig. 8A and Fig. S4) or BX-795 (Fig. S4), also reduced poly(I:C)-induced Akt P-S473, demonstrating that TBK1/IKKε activity positively controls mTORC2 signaling to Akt in RAW264.7 macrophages.We next isolated primary bone marrow derived macrophages (BMDMs) from Mtor and Mtor mice."
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"Our study provides evidence that TBK1 inhibition by amlexanox alleviates PQ induced ALI and may be a new therapeutic strategy."
32763286
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"Amlexanox, which is known to inhibit TBK1 and IKKepsilon selectively, is an approved drug for the treatment of bronchial asthma, allergic rhinitis, and conjunctivitis in Japan and elsewhere."
29951055
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"In line with this, a small molecule inhibitor of TBK1/IKKε axis, amlexanox, showed increased thermogenesis accompanied by elevated energy expenditure."
36175539
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"In vitro studies revealed that amlexanox blocks TBK1 as well [XREF_BIBR]."
30791439
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"Consistent with this view, global knockout of the cGAS-cGAMP-STING downstream target TBK1 or IRF3, or pharmacological inhibition of IkappaB kinase epsilon (IKKepsilon) and TBK1 by amlexanox, reduced body weight, enhanced insulin sensitivity, and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes."
31109939
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"Amlexanox blocks activity of TBK1 and IKKepsilon with a half maximal inhibitory concentration (IC50) of approximately 1-2 muM."
30791439
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"Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury."
32763286
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"Amlexanox, an inhibitor of RLR signaling pathway, specifically supresses the noncanonical IkB kinases IKKε and TBK1, and both are essential players for the coordination of IFN regulatory factor 3 (IRF3)- and NF-κB-mediated innate immune response [27, 28]."
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"Inhibition of TBK1 by amlexanox attenuates paraquat induced acute lung injury."
32763286
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"Recently, Reilly et al. [XREF_BIBR] discovered a small molecule inhibitor of IKKepsilon and TBK1 kinases called amlexanox, which has been shown to selectively inhibit both IKKepsilon and TBK1."
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"Finally, we tested amlexanox (AMX) which inhibits TANK binding kinase 1 (TBK1) and its adaptor protein TBK-binding protein 1 (TBKBP1) which has been reported to variously regulate Rab7a activity [40] or induction of IFN response genes [41] ."
35086559
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"Consistent with this view , global knockout of the cGAS-cGAMP-STING downstream target TBK1 ( 37 ) or IRF3 ( 38 ) , or pharmacological inhibition of IkappaB kinase epsilon ( IKKepsilon ) and TBK1 by amlexanox , reduced body weight , enhanced insulin sensitivity , and improved glucose tolerance in obese mice and in a subset of patients with type 2 diabetes ( 34,39 ) ."
31109939
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No evidence text available
eidos
"Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury ."
32763286
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"Amlexanox is a specific inhibitor of IKKepsilon and TBK1."
23396211
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"A study published in 2019 by Quan et al. provides evidence that amlexanox inhibits TBK1, thus inhibiting dendritic cell maturation and decreasing inflammation caused by the innate immune response on a standard mouse model [XREF_BIBR]."
33380937
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"Finally, we tested amlexanox (AMX) which inhibits 204 TANK binding kinase 1 (TBK1) and its adaptor protein TBK-binding protein 1 (TBKBP1) which 205 has been reported to variously regulate Rab7a activity (19) or induction of IFN response genes 206 (20)."
| DOI
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"Recently, amlexanox has been shown to inhibit TBK1 and IKKepsilon, both of which are induced in the liver and fat by high-fat diet mediated NF-kappaB activation [XREF_BIBR]."
27353409
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"Accordingly, inhibition of TBK1 by amlexanox reduced p62 aggregates and restored NSC maintenance and differentiation in Fip200 hGFAP cKO mice."
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"Amlexanox and BAY 11-7082 were used to inhibit TBK1 and NF-κB, respectively."
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