IndraLab

Statements

USP35 activates Carcinogenesis. 8 / 8
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"USP35 enhances tumorigenesis and stemness potentiality of PRAD cells."
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"In accordance to our speculations, USP35 overexpression could result in the formation of larger prostate tumors relative to those in control mice, suggesting that USP35 significantly promoted tumorigenesis (Fig. 2I)."
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"For example, USP35 promotes tumorigenesis in estrogen receptor (ER)-positive breast cancer by stabilizing and activating estrogen receptor α (Erα) to increases Erα transcriptional activity [19]."
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"We previously showed that deubiquitinase USP35 and ERalpha act in a positive feedback loop to promote the carcinogenesis of ER+ breast cancer although it is unclear whether USP35 regulates cell death in ER+ breast cancer."
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"Furthermore, BRD4 inhibitor (+)-JQ-1 inhibited USP35-enhanced tumorigenesis in vivo."
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"Similar effects have been observed in breast cancer, where USP35 enhances tumorigenesis by stabilizing estrogen receptor α (ERα), leading to increased proliferation and metastasis [37]."
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"Also, USP35 silencing could reduce NSCLC tumorigenesis by downregulating VEGFA."
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"USP35 promotes tumorigenesis of ER+ breast cancer via stabilizing and enhancing the transcriptional activity of ERα ."
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