IndraLab

Statements

YAP1 binds VCPIP1. 11 / 11
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"Biochemical assays demonstrated that VCPIP1 interacted with YAP, inhibiting K48-linked polyubiquitination and thereby increasing YAP stability."
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"Interestingly, the ChIP data indicated that YAP could bind to the promoter region of VCPIP1 and facilitate VCPIP1 transcription, which suggested the reciprocal regulation of VCPIP1 and the Hippo/YAP axis in PAAD."
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"VCPIP1 interacts with YAP and regulates YAP protein stability."
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"This result was consistent with our molecular docking analysis, which predicted that the OTU domain of VCPIP1 and the WW domain of YAP are responsible for the VCPIP1-YAP interaction (Fig. xref )."
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"We further depleted YAP in PAAD cells via siRNA and observed decreased binding of YAP to VCPIP1 promoter regions, as detected by a ChIP assay (Fig. xref D, E)."
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"YAP directly binds to the VCPIP1 promoter region, enhancing its transcription in PAAD."
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"On the other hand, YAP can directly bind to the VCPIP1 promoter region and facilitate its transcription."
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"Co-IP assays revealed the endogenous interaction of VCPIP1 and YAP in PAAD cells (Fig. xref D, E)."
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"A Co-IP assay demonstrated that the interaction between VCPIP1 and YAP requires the OTU domain of VCPIP1 and the WW domain of YAP (Fig. xref G, H)."
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biogrid
No evidence text available
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"VCPIP1 interacts with the YAP protein and facilitates its deubiquitination, which subsequently stabilizes and promotes its function."
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