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"These results indicated that Zn inhibited NLRP3 inflammasome activation in the HG treated HPMCs by activating the Nrf2 antioxidant pathway and reducing the production of ROS."

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"In conclusion, the present study demonstrated that HG induced NLRP3 inflammasome activation in HPMCs, whereas Zn treatment inhibited NLRP3 inflammasome activation by attenuating oxidative stress."