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USP20 inhibits TRAF6. 1 / 1

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"Thus, IRAK1 not only transduces IL-1R signaling (1) but also prevents its termination: phosphorylation of USP20 on Ser334 reduces USP20’s binding to TRAF6 and thereby diminishes (a) USP20-mediated deubiquitination/deactivation of TRAF6 and (b) consequent attenuation of downstream NFκB activation.USP20 is a member of the USP subfamily of DUBs, which are endowed with protein interaction domains that also participate in the activation process of these enzymes (31)."

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USP20 inhibits TRAF6. 1 / 1

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