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USP13 inhibits Neoplasm Metastasis. 5 / 5
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"Androgen receptors decrease the expression of USP13 by upregulating miRNA-539-3P, thus increasing the degradation of MITF protein by ubiquitination and promoting melanoma metastasis (85,86)."
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"In pulmonary metastatic models, a reduction in pulmonary metastasis caused by USP13 knockdown was abolished in 143B cells with METTL3 overexpression, while silencing METTL3 in HOS cells markedly counteracted the pro-metastatic influence of USP13 upregulation on pulmonary metastasis, as evidenced by histological analysis (Fig. 5f, g)."
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"Furthermore, we show in bladder injected-liver metastasis xenograft model that USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A."
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"Thus, targeting USP13 would suppress metastasis and progression in RAS -mutant tumors.USP13 has been implicated in cancer development through deubiquitinating both oncogenic and tumor-suppressive prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A."
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