IndraLab

Statements

KCNQ4 binds SsTx. 4 / 4
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"Structural and functional assays of the interaction between SsTx and Kv7.4 revealed that all of the basic residues on SsTx contributed to the inhibitory effect on Kv7.4."
32260499
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"To further validate interactions between the positively charged residues on SsTx and the negatively charged residues of KCNQ4, we applied thermodynamic mutant cycle analysis to experimentally investigate the molecular interactions between SsTx and KCNQ4 (XREF_FIG, Top)."
29358396
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"We therefore first investigated the interaction between SsTx and KCNQ4."
29358396
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"These mutant toxins preserved WT like structural features, suggesting that the reduced inhibition is caused by a direct interaction between SsTx and KCNQ4."
29358396