IndraLab

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KCNH2 activates PKA. 3 / 3
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"Current literature suggests effective methods to diminish hERG inhibitory effects of drugs include reducing lipophilicity (clogP) [29] and decreasing basicity (pKa) [30,31] ."
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"Although these cells have proven quite useful for studying many types of PKA modulation including HERG XREF_BIBR, K V 1.1 and nicotinic receptors XREF_BIBR, they appear less ideal for studying the modulation of L-type Ca 2+ channels."
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"We show that HERG associates with 14-3-3epsilon to potentiate cAMP and PKA effects upon HERG."
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